Age Related Eye Disease Study
The Age Related Eye Disease Study (AREDS) was a large clinical investigation sponsored by the US National Eye Institute to investigate the impact of vitamins (vitamins C and E) and minerals (copper and zinc) on the progression of AMD.
AREDS comprises of two studies AREDS1 and AREDS2
AREDS1 showed that high doses of antioxidant vitamins and minerals, including vitamins C and E, beta-carotene, zinc and copper, reduced the risk of progressing to advanced AMD by 25% and the risk of experiencing moderate vision loss by 19%.
In the AREDS-2 study the addition of lutein and zeaxanthin to the AREDS1 formula showed a further 10% decrease in the risk of progression to advanced AMD.